NITROMED'S NITRIC OXIDE TECHNOLOGY

Nitric Oxide (NO) technology provides stable and pharmaceutically elegant forms of NO to produce new NO-based compounds and extend the product lifecycle of existing medicines by adding an NO-donor. NO is one of the simplest and most versatile molecules in biology. The challenge of harnessing therapeutically active NO has been delivering biologically useful forms without instigating the potential toxicity associated with NO free radicals.

NitroMed believes that its technology mediates potential negative NO-reactions while providing key benefits to existing pharmaceuticals, thereby reducing the potential development of toxicity associated with NO free radicals and enabling the management of various functions and conditions including perfusion, gastric toxicity, male erectile response, coagulation, inflammation, and pulmonary hypertension. NitroMed's NitRx® technology is covered by an extensive patent portfolio and the principles of NO technology are well-established in scientific literature.

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