NITROMED PUBLICATIONS

Papers | Abstracts

McNamara, D.M., Tam, S.W., Sabolinski, M.L., Palmer, E., Tobelman, P., Janosko, K., Feldman, A.M., Worcel. M.  Beta 1 Receptor Gly389Arg Polymorphism and the Impact of Isosorbide  Dinitrate Hydarlazine in Heart Failure:  Results from the AHeFT trial 55th Annual Scientific Session of ACC, Atlanta, March 11-14 (2006)  #986-60

Taylor, A.L., Lindenfeld, J., Ziesche, S., Walsh, M.N., Mitchell, J., Adams, K., Tam,  S.W., Ofili, E., Sabolinski, M.L., Worcel, M., Cohn, J.N. Outcomes By Gender in the African-American Heart Failure Trial (A-HeFT) 55th Annual Scientific Session of ACC, Atlanta, March 11-14 (2006)  #837-8

Cohn, J.N., Tam, S.W., Anand, I.S., Worcel, M.,  Sabolinski, M.L., Taylor, A.L.  Clinical Outcomes by Baseline Left Ventricular Ejection Fraction in the African-American Heart Failure Trial. 55th Annual Scientific Session of ACC, Atlanta, March 11-14 (2006) #837-7

McNamara, D.M., Tam, S.W., Sabolinski, M.L., Palmer, E., Tobelman, P., Janosko, K., Feldman, A.M., Worcel. M.  Aldosterone Synthase Promoter Polymorphism Modulates Outcome In African-Americans With Heart Failure: Results From The AHeFT Trial. 55th Annual Scientific Session of ACC, Atlanta, March 11-14 (2006) #819-5

Anand, I.S., Tam, S.W., Rector, T.S., Archambault, W.T.,  Olukotun, A.Y., Adams, K.F., Worcel, M., Sabolinski, M.L., Taylor, A.L., Cohn, J.N.  Isosorbide Dinitrate-Hydralazine Decreased Blood Pressure in Patients with High But Not Low Blood Pressure and Improved Survival Independent of Baseline Blood Pressure in African-American Heart Failure Trial.  55th Annual Scientific Session of ACC, Atlanta, March 11-14 (2006) #809-3

Cheng J.W., Linde-Zwirble W.T., Tam S.W., Worcel M., Sabolinski M.L., Ghali J., Angus D.C.  Cost effectiveness of a fixed-dose combination of isosorbide dinitrate and hydralazine in blacks: results from the African-American Heart Failure Trial (A-HeFT)  American Society for Health System Pharmacists Midyear Clinical Meeting December 4-8, Las Vegas (2005) #378

Janero, D.R. In Vivo Metabonomic Profiling of the Bioeffector Nitric Oxide (NO): “NObonomics”.  Metabolic Profiling: Pathways in Discovery, Orlando, FL December (2005)

Dhawan V., Ellis, J.L., Schwalb, D.S., Shumway, M.J., Warren, M.C., Wexler, R.S., Zemtseva, I.S., Zifcak, B.M., Janero, D.R. Nitrite/Nitrate-driven Nitros(yl)ation Is Induced by chemically Diverse Organic Nitrate NO Donors In Vivo.  Annual Meeting of Society for Free Radical Biology and Medicine, Austin, TX., November 16-20 (2005)  

Dhawan V., Dubé, G.P., Ellis, J.L., Schwalb, D.S., Shumway, M.J., Warren, M.C., Zemtseva, I.S., Janero, D.R. .NObonomic Profiling Reveals that Hydralazine Enhances Bioavailable Nitric Oxide (NO) from Isosorbide Dinitrate In Vivo. Annual Meeting of Society for Free Radical Biology and Medicine, Austin, TX., November 16-20 (2005)  

Tam, S.W., Linde-Zwirble, W., Worcel, M., Sabolinski, M.L., Ghali, Villagra, V.G.,  Winkelmayer, W.C., Angus, D.C.  Cost Effectiveness of Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine Therapy for Black Patients with Heart Failure. AHA Annual Meeting, November 13-16 (2005) AHA Annual Meeting, November 13-16 (2005) published in Circulation 112:II-644 (2005)

Carson, P., Ghali, J., Tam, S.W., Worcel, M.  Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine Improves Quality of Life in African Americans with Heart Failure: Results from A-HeFT. AHA Annual Meeting, November 13-16 (2005) published in Circulation 112: 17S 643 (2005)

Anand, I.S.,  Tam, S.W., Archambault, W.T.,  Olukotun, A.Y. , Adams, K.F., Worcel, M., Sabolinski, M.L., Taylor, A.L., Cohn, J.N. Beneficial Effects of Isosorbide Dinitrate-Hydralazine on Survival in Heart Failure is Independent of its Blood Pressure Lowering Effect – Results From African American Heart Failure Trial.  AHA Annual Meeting, November 13-16 (2005) published in Circulation 112:II-642 (2005)

Cohn, J.N.; Anand, I., Taylor, A.,  Tam, S. Fixed-dose combination of isosorbide dinitrate and hydralazine inhibits left ventricular remodeling in well-treated severe heart failure in African Americans:  A-HeFT. AHA Annual Meeting, November 13-16 (2005) published in Circulation 112: I7S 642 (2005)

Cheng J.W., Linde-Zwirble W.T., Tam S.W., Worcel M., Sabolinski M.L., Ghali J., Angus D.C.  Economic evaluation of a fixed-dose combination of isosorbide dinitrate and hydralazine in black patients with heart failure: results from the African-American Heart Failure Trial (A-HeFT)  American College of Clinical Pharmacy (ACCP) Meeting, Oct 23-26, San Francisco (2005)

Ellis, J.L. NMI-1182, a Novel Gastro-Protective, Cyclo-Oxygenase-Inhibiting Nitric Oxide Donor.  Basic Research on Nitric Oxide Symposium at the 4th World Congress of Cellular and Molecular Biology, Poitiers, France October 7-12, (2005)

Cheng J.W., Linde-Zwirble W.T., Tam S.W., Worcel M, Sabolinski M.L., Ghali J, Angus D.C. Economic evaluation of a fixed-dose combination of isosorbide dinitrate and hydralazine in blacks with heart failure: results from the African-American Heart Failure Trial (A-HeFT) Academy of Managed Care Pharmacy 2005 Educational Conference October 5-8, (2005)

Cheng J.W., Linde-Zwirble W.T., Tam S.W., Worcel M., Sabolinski M.L., Ghali J., Angus D.C.  Economic evaluation of a fixed-dose combination of isosorbide dinitrate and hydralazine in black patients with heart failure: results from the African-American Heart Failure Trial (A-HeFT)  American Society for Health-System Pharmacists (ASHP) Meeting, (2005)

Cohn, J.N.; Anand, I., Taylor, A.,  Tam, S. Fixed-dose combination of isosorbide dinitrate and hydralazine inhibits left ventricular remodeling in well-treated severe heart failure in African Americans:  A-HeFT. 9th Annual Scientific Meeting of the Heart Failure Society of America, Boca Raton, FL September 18-21 (2005)

McNamara, D.M., Tam, S.W., Sabolinski, M.L., Palmer, E., Tobelman, P., Janosko, K., Feldman, A.M., Worcel. M. The Genetic Risk Assessment Sub-study of the African-American Heart Failure Trial (A-HeFT): Impact of Genetic Variation of NOS3. 9th Annual Scientific Meeting of the Heart Failure Society of America, Boca Raton, FL September 18-21 (2005) #232

Linde-Zwirble, W. T., Tam,S.W., Worcel, M.,. Sabolinski, M.L., Ghali, J., Angus, D.C. In-Trial Economic Evaluation of A Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure: Results from the African-American Heart Failure Trial (A-HeFT) 9th Annual Scientific Meeting of the Heart Failure Society of America, Boca Raton, FL September 18-21 (2005) #228

Carson, P., Ghali, J., Tam, S.W., Worcel, M.  Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine Improves Quality of Life in African Americans with Heart Failure: Results from A-HeFT. 9th Annual Scientific Meeting of the Heart Failure Society of America, Boca Raton, FL September 18-21 (2005) #223

Linde-Zwirble, W.T, Tam, S.W., Sabolinski, M.L., Ghali, J., Villagra,V.G., Winkelmayer, W.C., Angus, D.C. Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine Reduces Heart Failure Hospitalizations, Length of Stay, and Cost in A-HeFT (African-American Heart Failure Trial) 9th Annual Scientific Meeting of the Heart Failure Society of America, Boca Raton, FL September 18-21 (2005) #220

Taylor, A.L., Ziesche, S., Yancy, C.W.,  Carson, P., Ferdinand, K., Taylor, M., Adams, K., Olukotun, A., Ofili, E.,  Sabolinski, M., Worcel, M., Cohn, J.N., Early, Sustained Event-Free Survival From Fixed-Dose Isosorbide Dinitrate/Hydralazine, Increased Survival is Consistent Across Subgroups and Associated in Advanced Heart Failure. 9th Annual Scientific Meeting of the Heart Failure Society of America, Boca Raton, FL September 18-21 (2005) #218

Lin, C-E., Garvey, D.S.  Identification of the Nitrate Produced from g Radiation Sterilization of S-Nitrosoglutathione.  230th ACS  National Meeting, Washington, DC. August 28 –September 1 (2005) ANYL #174

Khanapure, S. P., Augustyniak, M. E., Dhawan, V., Earl, R. A., Ellis, J. L., Ezawa, M. , Garvey, D. S. , Gaston, R.D.,  Janero, D. R., Murty, M., Schwalb, D. J., Selig, W. M., Shumway, M.J., Trocha, A.M.,  Wey, S. J., Young, D.V., Zemtseva, I., Letts, L.G. Synthesis of 2,3-Bis(nitroxy)propyl esters of Naproxen, Indomethacin, Diclofenac and/or Aspirin and Pharmacogical Evaluation of a Novel Gastro-protective NMI-1182 As a Cyclooxygenase Inhibitor endowed with Nitric Oxide Donor (CINOD) 230th ACS  National Meeting, Washington, DC. August 28 –September 1 (2005) MEDI #295

Letts, L.G., Augustyniak, M.E., Cochran, E.D., Dhawan, V., Earl, R.A., Ellis, J.L., Ezawa, M., Gordon, L.J., Garvey, D.S.,  Janero, D.R., Khanapure, S.P., Melim, T.L., Murty, M.G., Shumway, M.J., Schwalb, D.J., Selig, W.M., Trocha, A.M., Young, D.V., Zemtseva, I.S.  NMI=1182: A New Gastroprotective CINOD.  International Eicosanoids Conference Basic Science & Clinical Applications; Beijing, China; July 4-6 (2005)

Khanapure, S. P., Garvey, D.S. A Highly Efficient Microwave Assisted Suzuki-Miyaura Cross-Coupling of Less Reactive Heteroaryl Chlorides and Arylboronic Acids Using Air-Stable Palladium–Phosphinous Acid Complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a Catalyst, and Its application to Convenient Synthesis of a Novel Cyclooxygenase-2 (COX-2) Selective Inhibitor.  Microwave Assisted Organic Synthesis, Boston, MA, May 26 (2005)

Wong, H.L., Ellis, J.L., Gordon, L.J., Melim, T.L., Selig, W.M.  Altered blood pressure responses to angiotensin II in Dahl salt-sensitive rats on a high salt diet. FASEB Meeting on Experimental Biology, San Diego, CA., April 2-6 (2005) #87.8

Wexler, R.S., Gordon, L.J., Melim, T.T., Wong, H.L., Zifcak, B.M., Ellis, J.L.
A Novel In Vivo Model of Nitrate Tolerance: Transdermal Infusion of Nitroglycerin in Telemeterized Rats. FASEB Meeting on Experimental Biology, San Diego, CA, April 2-6 (2005) #319.14

Melim, T.L., Ellis, J.L., Gordon, L.J., Selig, W.M., Sturino, C., Wexler, R.S. Wong, H.L. Cyclooxygenase-2 Inhibition and Blood Pressure Response to Angiotensin II in Telemeterized Wistar Rats. FASEB Meeting on Experimental Biology, CA., San Diego, CA, April 2-6 (2005) #87.17

Janero, D.R., Bryan, N.S., Dhawan, V.,  Schwalb, D.J., Warren, M.C.,  Feelisch, M. NObonomics:  in vivo global metrics of nitric oxide-donor pharmacology. FASEB Meeting on Experimental Biology, San Diego, CA, April 2-6 (2005) #687.27

Dhawan, V., Bryan, N.S., Janero, D.R., Schwalb, D.J., Warren, M.C., Feelisch M. NObonomics: profiling the in vivo global dynamics of nitric oxide drug. Massachusetts Biotech Council “Discovery Day” Poster, Boston, MA, March 18 (2005)

Wey, S-J., Augustyniak, M.E., Cochran, E.D., Ellis, J.L., Fang, X.-Q., Garvey, D.S.,  Janero, D.R., Letts, L.G., Martino, A.M., Melim, T.L., Murty, M.G., Richardson, S.K., Schroeder, J.D., Selig, W.M., Trocha, A.M., Young, D.V., Zemtseva, I.S. Structure-Based Modification of Indomethacin as Cyclooxygenase-2 Inhibiting Nitric Oxide Donor. 229th ACS National Meeting, San Diego, CA, March 13-17 (2005) MEDI-194

Ezawa, M.,  Garvey, D.S., Janero, D.R., Khanapure, S.P., Letts, L.G.,  Martino, A.,  Ranatunge, R.R.,  Schwalb, D.J., Young, D.V. Synthesis of a Heteroaryl Modified, 1, 5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor. 229th ACS  National Meeting, San Diego, CA, March 13-17 (2005) MEDI-223

Young, D.V., Cochran, E.D., Earl, R.A., Ellis, J.L., Garvey, D.S., Khanapure, S.P.,  Letts, L.G., Melim, T.L., Murthy, M.G., Selig, W.M.  The CINOD, NMI-1182, Inhibits Cyclooxygenase in Human Blood and Releases Bioactive Nitric Oxide in Kidney Cells and Hepatocytes.  Annual Meeting of American Society for Cell Biology, Washington, D.C.  December 4-8 (2004)

Dhawan,V.,  Bryan, N.S.,  Janero, D. R.,  Saijo, F., Schwalb, D.J., Warren, M.C., Feelisch, M.  Glyceryl trinitrate induces selective nitros(yl)ation of blood and tissue components in vivo: A  nitric oxide metabonomic (NObonomic) approach. Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) St Thomas, Virgin Island. November 17-21 (2004)

Cochran, E.D., Dhawan, V., Earl, R.A., Ellis, J.L., Garvey, D.S., Janero, D. R., Khanapure, S.P., Letts, L. G., Murty, M.G., Selig, W. M., Shumway, M. J.,  Zemtseva, I. S., Young, D.V.  Metabolic Fate of the CINODs, NMI-1182 and AZD3582, in Human Blood and Tissue Fractions.  12th International Conference of the Inflammation Research Association. Sagamore, NY. October 3-7 (2004) A092

Schwalb, D.J., Augustyniak, M.E., Earl, R. A.,  Ellis, J.L., Garvey, D.S., Gordon, L.J.,  Janero, D. R., Khanapure, S.P., Letts, L. G., Melim, T.L., Shumway, M. J., Selig, W. M., Trocha, A.M., Young, D.V.,  Zemtseva, I. S. NMI-1182, a Gastroprotective Cyclooxygenase Inhibiting Nitric Oxide Donor (CINOD):  Anti-Inflammatory Activity in the Rat.  12th International Conference of the Inflammation Research Association. Sagamore, NY. October 3-7 (2004) A114

Ranatunge, R.R., Augustyniak, M., Dhawan, V., Ellis, J.L., Garvey, D.S.,  David Janero, D.R.,  Letts, L.G., Richardson, S.K., Shumway, M.J., Trocha, A.M., Young, D.V., Zemtseva, I.S.  The Synthesis and Anti-inflammatory Activity of a Series of N-Substituted Glycolamides of Naproxen: Nitric Oxide Donor Contains Naproxen Prodrugs.  228th ACS  National Meeting, Philapdelphia, PA. August 22 -26 (2004) MEDI-247

Khanapure, S.P., Augustyniak, M.E., Earl, R.A.,  Garvey, D.S., Letts, L.G., Martino, A. M., Murthy, M. G.;  Schwalb, D.J., Shumway, M.J., Trocha, A.M., Young, D.V.,  Zemtseva, I. S., Janero, D.R.  A Potent and Highly Selective Cyclooxygenase-2 (COX-2) Inhibitor from a Novel Pyridyl Metharyl Series.  228th ACS  National Meeting, Philapdelphia, PA. August 22 -26, (2004) MEDI-243 

Shumway, M.J., Augustyniak, M.E., Earl, R.A.,  Ellis, J.L., Garvey, D.S., Gordon, L.G., Janero, D.R., Khanapure, S.P.,  Letts, L.G., Melim, T.L., Schwalb, D.J., Selig, W.M.,  Trocha, A.M., Young, D.V.,  Zemtseva. I. S.  The Novel Cyclooxygenase Inhibiting Nitric Oxide Donor (CINOD), NMI-1182, Attenuates Inflammation in the Rat Air Pouch Model. FASEB Journal   VOL. 18   NO. 4-5   2004   PP. Abst. 408.10. FASEB Meeting on Experimental Biology, Washington D.C. April 17-21 (2004) A5875

Trocha, A.M., Augustyniak, M.E., Earl, R.A.,  Ellis, J.L., Garvey, D.S.,  Janero, D.R., Khanapure, S.P., Letts, L.G., Schwalb, D.J., Selig, W.M.,  Shumway, M.J.,  Zemtseva. I. S.  NMI-1182:  A Novel, Gastroprotective, Orally Bioavailable Cyclooxygenase Inhibitory Nitric Oxide Donor (CINOD) in the Rat Paw Edema Inflammation Model. FASEB Meeting on Experimental Biology, Washington D.C. April 17-21 (2004) A5799

Trocha, A.M., Shumway, M., Augustyniak, D., Young, D., Janero, D., Letts, G.  Six-Day Rat Carrageenan Air-Pouch Model: Development and Response to Anti-Inflammatory COX-2 Selective Inhibitors.  Sixth World Congress on Inflammation, Vancouver, August 2-6 (2003)

Augustyniak, M., Bandarage U.K, Earl, R.A., Fang, X., Garvey, D.S., Janero, D.R.,  Khanapure, S.P., Letts, L.G.,  Martino, A.M.,  Murty, M.M., Ranatunge, R.R., Schroeder, J.D., Shumway, M.J., Troch, A.M., Young, D.V., Zemtseva, I.   Synthesis and Structure-Activity-Relationships of a Series of Novel Nitric Oxide Donor Containing Selective Cyclooxygenase-2 Inhibitors.  Sixth World Congress on Inflammation, Vancouver August 2-6 (2003)

Janero, D.R., Augustyniak, M., Cochran, E., Earl, R., Ezawa, M., Fang, F., Garvey, D.S.,  Gaston, R., Khanapure, S., Letts, G.L., Marek, P., Ranatunge, R., Shumway, M.,  Stevenson, C., Trocha, M., Wey, S.-J.,Young, D.  Novel Nitrated Cyclooxygenase-2 (COX-2) Selective Inhibitors:  Improved Anti-inflammatory Medicines with Gastroprotective Properties, Experimental biology Meeting, San Diego. FASEB J. 17:A1344 (2003)

Garvey, D.S.,  Janero, D.R., Letts, L.G.,  Martino, A.M.,  Murty, M.G.,  Ranatunge, R.R.,  Richardson, S.K.,  Schroeder, J.D., Young, D.V., Zemtseva, I.S.  Structure-Activity Relationship of a Series of Novel Bicyclic Pyrazoles as Selective Cyclooxygenase-2 (COX-2) Inhibitors, Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, March 23-27 (2003)     MEDI-245

Ezawa, M., Khanapure, S.P., Garvey, D.S., Young, D., Earl, R., Gaston, R., Frank, R., Fang, F., Marek, P., Shumway, M., Trocha, M., Tam, S.W., Janero, D.R., Letts, L.G.:  Design and synthesis of novel benzo-dioxolane metharyl cyclooxygenase-2 (COX-2) selective inhibitors Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27 (2003)  MEDI-243

Janero, D.R., Cochran, E., Fang, X.,  Garvey, D.S.,  Letts, L.G.,  Marek, P., Schroeder, J.  Nitric oxide donor adition renders cyclooxygenase-2 (COX-2) selective inhibitors anti-thrombotic in vivo. Gut 51 (suppl III): A18 (2002)

Schroeder, J. D., Augustyniak, M.,  Bandarage, R. R.,  Bandarage, U. K.,  Cochran, E., Earl, R.,  Ezawa, M., Fang, X.,  Garvey, D. S.,  Gaston, R. D.,  Janero, D. R.,  Khanapure, S. P.,  Letts, L. G.,  Marek, P.,  Martino, A., Murty, M.,  Saha, J.,  Shumway, M., Stevenson, C. A.,  Tam, S. W., Trocha, M.,  Wey, S.-J.,  Young, D. V.  NMI-1093: A nitric oxide-enhanced cyclooxygenase-2 selective inhibitor with cardioprotective potential.    Abstracts of Papers, 224th ACS National Meeting, Boston, MA, August 18-22 (2002) MEDI #316

Khanapure, S.P., Garvey, D.S., Young, D., Ezawa, M., Earl, R., Gaston, R., Fang, F., Schroeder, J., Marek, P., Murty, M., Martino, A., Shumway, M., Trocha, M., Tam, S.W., Janero, D., Letts, L. G.   Discovery, synthesis, and structure-activity profile of novel highly potent metharyl COX-2 selective inhibitors.  Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22 (2002)  MEDI-315

Bandarage, R. R., Augustyniak, M. E., Bandarage, U. K., Cochran, E. D., Earl, R. A., Garvey, D. S., Janero, D. R., Letts, L. G., Marek, P., Martino, A. M., Murty, M. G., Richardson, S. K., Schroeder, J. D.,  Shumway, M. J., Tam, S. W., Trocha, A. M., Young, D. V.  Synthesis and COX-2 inhibitory activity of a series of novel pyrazoles.    Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22 (2002)  MEDI-314

Garvey, D.S., Augustyniak, M.  Earl, R., Janero, D.R., Letts, L.G., Schroeder, J.,  Shumway, M., Trocha, M.  2002.  NMI-2398, a novel cyclooxygenase-inhibiting NO donor. Proceedings of XIVth World Congress of Pharmacology, San Francisco, CA, (2002) # LB23

Janero, D.R., Augustyniak, M., Cochran, E.,  Fang, F.,  Garvey, D.S.,  Letts, L.G., Schroeder,  J.D.,  Trocha, M., Young, D.   Novel nitrated cyclooxygenase-2 (COX-2) selective inhibitors are anti-thrombotic in vivo.  Proceedings of XIVth World Congress of  Pharmacology, San Francisco, CA, (2002) # LB11

Janero, D.R., Augustyniak, M., Bandarage, R.,  Bandarage, U.,  Cochran, E.,  Earl, R., Fang, F.,  Garvey, D.S.,  Gaston, R.,  Khanapure, S.,  Letts, L.G.,  Marek, P., Martino, A., Murty, M., Stevenson, C., Schroeder, J.,  Shumway, M., Tam, S.W.,  Trocha, M., Wey, S.-J., Young, D.V.  Nitrated cyclooxygenase-2 (COX-2) selective inhibitors:  potentially improved cardiovascular risk profile.  In:  Proceedings of the Society for Experimental Biology and Medicine, Washington, D.C., (2002), # 1

Lin, C.-E., Garvey, D.S., Janero, D.R., Letts, L.G., Marek, P., Richardson, S.K., Shumway, M., Tam, S.W., Trocha, M., Young, D.: Design and synthesis of nitrosylated paclitaxel (NO-paclitaxel) and adamantanyl nitric oxide donor as antirestenosis agents. Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, United States, April 7-11 (2002), MEDI-036

Augustyniak, M.,  Bandarage, R.,  Bandarage, U.K., Bayliss, S., Cochran, E., Earl, R.A.,  Fang, X., Garvey, D.S.,  Gaston, R.D.,  Janero, D.R.,  Khanapure, S.P., Letts, L.G., Marek, P., Martinio, A., Murty, M., Quickley, C.A., Schroeder, J.D.,  Shumway, M.,  Tam, S.W., Trocha, M., Wey, S.-J., Young, D.V.  Nitrated COX-2 Selective Inhibitors: a reduced cardiovascular risk profile?” #P 9, William Harvey Research Conference: Progress in the Field of Selective COX-2 Inhibitors, Nice, France (2001)

Lin, C-E., Richardson, S.K.  Using L-cysteine as a water-soluble cation scavenger in the removal of a 2,4,6-trimethoxybenzyl group from thiols with trifluoroacetic acid.    Abstracts of Papers - 221st American Chemical Society, (2001) ORGN-529

Saha, J.K., Wang, T., Richardson, S.,  Trocha, M., Shumway, M.,  Garvey,  D., Letts, L.G., Wolfe, M.M.,  Tam, S.W.  Enhanced Gastroprotective and Anti-ulcerogenic Activities in Rats of a New Class of Proton Pump Inhibitor Containing Nitrosothiol Nitric Oxide Donor, Digestive Disease Week (2001)

Janero, D.R., Garvey, D.S., Letts, L.G., Lin, C.-E., Marek, P., Richardson, S.K., Serebryanik, D., Shumway, M., Tam, S.W., Trocha, M., Wang, T., Wu, T. Young D.: Stents Coated with a Combination of Nitric Oxide Donor and Nitrosylated Taxol, but Not Taxol Alone, Reduce Stenosis in the Rabbit Iliac Artery.  FASEB J.  15:A1226 (2001)

Saha, J.K., Bandarage, U.K.,  Schroeder, J.D.,  Garvey, D.S., Chen, L.,  Glavin, A., Janero, D.R.,  Letts, L.G.,  Tam, S.W.  NMI-377, a nitric oxide-donating diclofenac derivative with gastroprotective properties.  Gastroenterology  118:A1301 (2000)

Bandarage, U.K., Chen, L., Fang, X., Garvey, D.S., Glavin, A., Janero, D.R., Letts, L.G., Mercer, G.J., Saha, J.K., Schroeder, J.D., Shumway, M.J., Tam, S.W.:  Synthesis and Biological Evaluation of Nitrosothiol Esters of Diclofenac as a New Class of Gastrointestinal-sparing Prodrugs.  Synthesis and biological evaluation of nitrosothiol esters of diclofenac as a new class of gastrointestinal-sparing prodrugs.    Abstracts of Papers - 220th  American Chemical Society  (2000), MEDI-242

Quickley, C. A., Khanapure, S., Gaston, R. Facile synthesis of substituted thiomorpholin-3-ones.    Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30 (2000) 

Earl, R.A.,  Shelekhin, T.,  Khanapure, S.P.,  Quickley, C.A., Gaston, R.D.,  Wang, T., Schroeder, J.D., Garvey, D.S., Marek, P., Trocha, M.,  Jablonski, T.J.,  Wu, T., Letts, L.G., Tam, S.W.,  Fernandez, A., Cuevas, B., Gabancho,S., Martinez, V., Angulo, J., Saenz de Tejada, I.  Nitrosylated a-Adrenergic Receptor Antagonists as Potential      Agents for the Treatment of Erectile Dysfunction, 219th ACS National Meeting, San Francisco, CA, March 26-30 (2000),   MEDI-239

Gaston, R., Garvey, D.S., Saenz de Tejada, I., Angulo, J. Synthesis of Nitrated PGE1s and their Use in the Treatment of Male Erectile Dysfunction. 219th ACS National Meeting, San Francisco, CA, March 26-30 (2000) MEDI-238

Young, D.V.,  Richardson, S.K.,  Lin, C.-E., Wang, T., Serebryanik, D., Garvey,  D.S., Tam, S.W.,  Letts, L.G.,   Nitrosylation of Synthetic Taxol Derivatives Confers Antiplatelet Functionality While Retaining Antiproliferative Activity, American Society for Cell Biology 40th Annual Meeting, San Francisco, CA (2000), Abstr. #1212.

Tam, W., Wang, T., Glavin, A., Richardson, S., Trocha, M., Shumway, M., Garvey, D., Letts, G., Wolfe, M., Saha, J.: Nitric oxide-donating proton pump inhibitor with enhanced anti-ulcerogenic activities.  Gut 47 (Suppl III): A79, (2000)

Bandarage, U.K., Chen, L., Dong, Q., Fang, X., Garvey, D.S., Glavin, A., Janero, D.R., Letts, L.G., Mercer, G.J., Pai, R.P., Qin, C., Saha, J.K., Schroeder, J.D., Shumway, M.J., Tam, S.W. Synthesis and Pharmacological Evaluation of Gastrointestinal-sparing Nitrosothiol Esters of Non-steroidal Anti-inflammatory Drugs (NSAIDs)  Abstract.  The First International Conference Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, San Francisco, CA, June, A1358  (2000)

Saha, J.K., Wang, T., Glavin, A., Chen, L., Garvey, D.S., Letts, L.G., Tam, S.W.   Nitric oxide donating H2-receptor antagonist and proton pump inhibitor with enhanced anti-ulcerogenic activities in rats.  Abstract.  American Society for Biochemistry and Molecular Biology and American Society for Pharmacology and Experimental Therapeutics Joint Annual Meeting, Boston, MA, June, 2000.  FASEB J. 14(8): A1556, (2000)

Bandarage, U.K., Chen, L., Dong, Q., Fang, X., Garvey, D.S., Glavin, A., Janero, D.R., Letts, L.G., Mercer, G.J., Pai, R.P., Qin, C., Saha, J.K., Schroeder, J.D., Shumway, M.J., Tam, S.W.  Synthesis and Pharmacological Evaluation of Gastrointestinal-sparing Nitrosothiol Esters of Non-steroidal Anti-inflammatory Drugs (NSAIDs)  Abstract.  American Society for Biochemistry and Molecular Biology and American Society for Pharmacology and Experimental Therapeutics Joint Annual Meeting, Boston, MA, June, 2000.  FASEB J. 14(8): A1358 (2000)

Saha, J.K., Bandarage, U.K., Chen, L., Glavin, A., Janero, D.R.,  Garvey, D.S.,  Schroeder, J.D.,  Letts, L.G., Tam, S.W. NMI-377, A Novel Nitrosothiol- Diclofenac NSAID with Gastrointestinal-Sparing Antiinflammatory and Analgesic Activities. Annual Meeting of the American Gastroenterological Association, San Diego, CA (2000)

Young, D.V., Serebryanik, D., Tam, S.W.   Suppression of Human Coronary Artery Smooth Muscle Cell Proliferation by Nitric Oxide is cGMP-Independent. American Society for Biochemistry and Molecular Biology and American Society for Pharmacology and Experimental Therapeutics Joint Annual Meeting, Boston, MA, June, 2000.  FASEB J. 14(8): A1375 (2000)

Saha, J.K., Glavin, A., Chen, L., Letts, L.G., Tam, S.W.   Relaxation of Rabbit Corpus Cavernosum muscle by Pinacidil: role of Nitric Oxide and K+-Channel.  1st International Meeting, Biology, Chemistry and Therapeutic Effects of Nitric Oxide, San Francisco, CA, June 2000

Young, D.V., Serebryanik, D., Bandarage, R., Richardson, S., Janero, D., Garvey, D., Tam, S.W.,  Letts, L.G.: Differences in Antiproliferative Action of Nitric Oxide Donors in Cultured Human Coronary Artery Smooth Muscle Cells; American Society of Cell Biology Annual Meeting, San Francisco, CA, December, 1999.  Mol. Biol. Cell 10: 38a, (1999)

Dong, Q., Fang, X., Schroeder, J.D., Garvey, D.S. Practical, Efficient Synthesis of b-amino Thiols via Aminolysis Ring-opening of Thiiranes,  218th ACS National Meeting, New Orleans, Aug. 22-26 (1999)  ORGN #132    

Bandarage, U.K., Saha, J.K., Schroeder, J.D., Garvey, D.S., Mercer, G.J., Chen, L., Glavin, A., Janero, D.R., Letts, L.G., Tam, S.W.:  NMI-377, a nitric oxide-donating diclofenac derivative with gastroprotective properties.  218th ACS National Meeting, New Orleans, Aug. 22-26 (1999) MEDI-081

Tam, S.W., Saha, J.K., Garvey, D.S., Schroeder, J.D., Bandarage, U., Dong, Q., Janero, D.R., Chen, L., Shelekhin, T.E., Glavin, A., Letts, L.G.:  Nitric Oxide-Donating NSAIDs.  Abstract.  International Conference on Inflammopharmacology and Sixth Symposium on Side-Effects of Anti-Inflammatory Drugs.  Chateau Elan, Braselton, GA., May 23-26 (1999)

Saha, J.K., Bandarage, U.K., Janero, D.R., Chen, L., Glavin, A., Garvey, D.S., Schroeder, J.D., Letts, L.G., Tam, S.W.   Nitric oxide releasing diclofenac derivative NMI-346 is a novel gastrointestinal sparing NSAID.  The Annual Meeting of the American Gastroenterological Association at Digestive Disease Week, Orlando, FL, May, 1999.  Gastroenterology 116: A298 (1999)

Letts, G., Garvey, D., Marek, P., Saha, J., Schroeder, J.,  Shelekhin, T., Tam, W., Trocha, M., Cuevas, P., Cuevas, B., Fernandez, A.,  Gabancho, S.,  Saenz de Tejada, I.  The Role of Nitric Oxide in Impotence, Nitric Oxide:  Basic research and Clinical Applications, Paris (1998)

Saha, J.K., Bandarage, U.,  Janero, D.R., Chen, L., Garvey, D.S., Schroeder, J.D., Ewing, J.F., Letts, L.G., Tam, S.W.  NMI-346, a novel nitrosothiol diclofenac derivative as gastroprotective anti-inflammatory and analgesic drug.  Abstract.  9th International Conference, Inflammation Research Association, Hershey, PA, November 1-5 (1998)

Tam, S.W., Garvey, D.S., Chen, L., Schroeder, J.D., Shelekhin, T.E., Dong, Q., Janero, D.R., Letts, L.G., Saha, J.  Nitrosothiol-based nitric oxide moieties provide NSAIDs with gastroprotective properties and accelerate gastric ulcer healing in rats.  Abstract.  9th International Conference, Inflammation Research Association, Hershey, PA, November 1-5 (1998)

Saha J.K., Schroeder, J.D.,  Chen, L., Shelekhin, T.E., Dong, Q., Garvey, D.S.,  Letts, L.G., Tam, S.W.  Nitrosothiol-based SNO-NSAIDs as novel anti-inflammatory, analgesic drugs with reduced gastrointestinal toxicity.  Abstract.  Gastroenterology 114(4): A274 (1998)

Young, D.V., Janero, D.R., Serebryanik, D., Garvey, D.S.  Inhibition of Proliferation of Human Coronary Artery Smooth Muscle Cells by Nitrosothiol NO Donors.  American Society for Cell Biology 38th Annual Meeting, San Francisco, CA.  Mol. Biol. Cell  9:370a (1998) 

Janero, D.R, Ewing, J.F.  Specific S-nitrosothiol (thionitrite) quantification as solution nitrite after vanadium(III) reduction and ozone chemiluminescent detection.  Free Radical Biol. Med.  25:S62, (1998) 

Janero, D.R., Ewing, J.F., Grinnell, T.A., Schroeder, J.D., Garvey, D.S.  NADH as nitrosation substrate in nitric oxide-dependent posttranslational protein modification.  Free Radical Biol. Med.  23:2-43 (1997)

Saenz de Tejada, I., Cuevas, P., Cuevas, B., Fernandez, A., Gabacho, S., Letts, L.G., Schroeder, J.D., Shelekhin, T., Tam, S.W., Garvey, D.S.:  Nitrosylated a-adrenergic receptor antagonists as potential drugs for the treatment of erectile dysfunction.  Society for Urology, Annual Meeting, New Orleans, LA. (1997)

Saha J.K., Thomas, G., Marek, P., Kitabjian, R.F., Janero, D.R., Letts, L.G., Tam, S.W.  Nitrosothiol protects against acute and subchronic gastric muscosal damage induced by piroxicam in rats.  Abstract.  Annual Meeting of American Gastroenterological Association and American Association for the Study of Liver Diseases, May 11-14 (1997) Gastroenterology 112(4), A399, (1997)

Garvey, D. S., Richardson, S. K.; Schroeder, J.D.; Shelekhin, T.E.; Marek, P.; Saha, J. K.; Tam, S. W. Letts, L. G.  Nitric-oxide tethered NSAIDs: Anti-inflammatory, analgesic and gastro-protective agents.    Book of Abstracts, 214th ACS National Meeting, Las Vegas, NV, September 7-11 (1997), MEDI-036

Saenz de Tejada, I., Cuevas, P., Cueyas, B., Fernandez, A., Schroeder, J.D.,  Shelekhin, T., Letts, G.L., Garvey, D.S.  S-Nitrosylated Alpha Blockers as Potential Drugs for the Treatment of Impotence:  Biological Activity of NMI-187 and NMI-221, Int. J. Impotence Res., 8, 103 (1996)

Tam, S.W., Saha, J.K., Garvey, D.S., Schroeder, J.D, Richardson, S.K., Marek, P., Shelekhin, T., Fundeklian, R., Letts, L.G.  Nitric oxide adducts inhibit induction of gastric ulcers by nonsteroidal antiinflammatory drugs in the rodent.  Biochemistry and Molecular Biology of Nitric Oxide, An International Conference, Los Angeles, CA, July 13-17 (1996)

Tam, S.W., Saha, J.K., Garvey, D., Schroeder, J., Richardson, S., Marek, P., Shelekhin, T., Fundeklian, R., Letts, L.G.  Nitric oxide adducts inhibit nonsteroidal antiinflammatory drug induced gastric ulcers.  The Fourth Annual Midwest Meeting of the Inflammation Research Association.  Therapeutic Approaches to Allergic and Inflammatory Diseases.  Chicago, IL, March 6 (1996)

Janero, D.R., Ewing, J.F., Garvey, D.S., Young, D.V., Thomas, G., Grinnell, T.A., Letts, L.G.  A polynitrosated derivative of bovine serum albumin (NMI-139) is antiproliferative against human coronary-artery smooth muscle cells.  Proceedings of the Second International Conference on the Biochemistry and Molecular Biology of Nitric Oxide. 117 (1996) 

Ewing, J.F., Janero, D.R.  Microplate superoxide dismutase assay employing a non-enzymatic superoxide generator.  Free Radical Biol. Med.  19 (supplement): 54, (1995)